Personally, I don't feel 'unarmed' with a .380. My most carried pocket gun now - in fact, my most carried gun - is my S&W 642. Still, the P3AT gets pocket carried, some, in pants where the pockets just don't fit the 642 as well. I am comfortable with .380 for self defense because I figure that, honestly, most assailants are going to stop after you shoot them once with anything and any assailant that won't - say, one that feels no pain and is temporarily 'superhuman' because of some kind of drug use - probably isn't going to stop for anything short of a 12 gauge with 00 buckshot. In other words, I think that a (lucky) CNS shot with a .380 will stop an assailant just as quickly as a (lucky) CNS shot with a 9mm, .45, etc., a marginal shot with a .380 is just as capable of causing a 'psychological' stoppage as a 9mm, .45, etc. and a 9mm, .45, etc. isn't that much if any more likely to cause a 'psychological' stop on a drugged-out or crazy/determined assailant than a .380. Of course, that is just my opinion. I also have to consider that, for something of a size/weight that I can carry it in my pocket or that will even completely disappear in an OWB holster the .380 and .38 are a lot more controllable - meaning more accurate and faster follow up shots - than a 9mm, .45, .357 and so on of the same or very similar size and weight. That is part of the reason I sometimes like to carry my CZ 82. Yeah, it is pretty much as big as some of the small 9mm Luger pistols, it isn't super light (but not super heavy, either) and 9mm Makarov is probably not that much more powerful than a .380 but I can shoot the heck out of that CZ quickly and accurately and it carries 12 rounds in a flush fit mag so 12+1 total capacity. I still carry old-school Federal Hydra shoks in the P3AT as tests I have seen indicate it gives some expansion, albeit not huge expansion, and consistently deep penetration. I managed to pick up a couple of boxes of 9mm Mak Critical Defense for the CZ.
None of that is to say that I never carry anything bigger but in warmer months when I don't want to constantly wear a cover garment, etc. - which with the combination of me being hot-natured and the average temp in Tennessee works out to be 8 months or so out of the year - I usually prefer pocket carry, always with a pocket holster. That is just me, though.