Unless yo just plain run into an emergency and must pull the trigger, always, always always use safety glasses when shooting, especially pistols.
Had a double charged .45 case grenade on me a few weeks ago, blew the CM shooting star mag out, reseated the next round 1/8 further in and scorched the bullet blasted the welded base off the mag, launched the mag spring 20' away, filled my action with scorched brass granules cut my face in 4 places, punched through my nostril so my nose was bleeding internally and externally, put 3 scratches into and imbedded another chunk of brass in my safeties, without safeties, at least one of those would have gone through my lower eyelid and probably punctured the eyeball.
Scared the heck out of me and convinced me of the need to protect my eyes well when shooting.
That said, being that the .22 mag is hypersonic, it will always be somewhat loud and that it is a hybrid action, you probably do not want to deliberately increase the pressures, might take it, might not. Get a .22lr for your can.