I've never shot a 10mm. Don't they kick like a mule? I've always considered 10mm to be impractical for self defense, much like .44mag. Overpowered, and just too difficult to practice enough to learn how to control the recoil, if you ever can. I don't have trouble controlling .44mag ... for the initial shot. Followup shots would be all over the place, unless you allowed me several seconds to regain my wits. I'd expect the 10mm to be similar.
Negative. Recoil with the 10mm loads I've tried with the conversion barrel in my G21 has been no worse than .45 ACP through the same. Part of that may be due to the aforementioned "meh" loads (although the Winchester Silvertips I ran through it were pretty hot), but most I would attribute to the size/build of the G20/G21 frame and the aftermarket 22# spring that I'm using with it (instead of the 17# factory spring). The recoil impulse is faster, but not heavier, and the report is louder but nothing anywhere near as loud as a .357 Magnum or .22 TCM. And in terms of ballistics, the 10mm is not "overpowered" in terms of penetration, as long as you're not running hard cast lead, FMJ's, or Lehigh Extreme Penetrators for defense against humans. (If defending against bears and other woodland predators, though, that would be a good thing.) Winchester Silvertips and loads using the Barnes copper bullet or Gold Dot bullet have all performed quite nicely in testing - over 12", but under 18", with lots of expansion.
Have you handled a SF yet?
I have a 20 and two 21s, but I've never handled a slim frame.
Prior to the basic Gen3 G21 that I currently have, I once had a G21SF. Still kicking myself in the butt for getting rid of it.

I've compared 'em side-by-side at the LGS a couple of times, and the difference in feel is significant. The SF frame feels more like the G19 to my hand, whereas the plain G20/G21 frame feels like ... well...
I'm not sure it is practical, but I sure like the idea.
Recoil control, even at speed, is a learnable skill.
Why wouldn't it be practical? This isn't a .50 AE Desert Eagle (or even a .50 GI conversion). I've fired the 10mm-converted G21 one-handed, both right and left. It never flew out of my hand or whacked me in the head or anything wild like that; rather, it recoiled much like .45 ACP, although it was more of a "bump" rather than a "push." Actually, follow-up shots with 10mm were a tad quicker for me than with .45 ACP.
I haven't tried 10mm out of anything else yet because the other platforms I've looked at (the 10mm 1911 and Tanfoglio Witness conversion) seem to be problematic at best in terms of reliability, so I can't attest to whether the G20/G21 platform is the easiest-recoiling setup available. But I do know that mine feels quite acceptable overall. I'm just not convinced of the reliability of the conversion barrel that I have, at least not enough to trust it for carry, plus the whole "he used a highly customized super death ray gun!" factor of a caliber-swapped carry gun (I'd prefer a factory-chambered 10mm to minimize the lawyer bait).
FWIW, Mechtech does make a carbine conversion for the G20/G21 in 10mm. Seems neat, but I don't really have much use or desire for a pistol-caliber semi-auto carbine.