I was exploring this myself, with my new Gen2 (I had a Gen1 a few years ago) with a few tubes I have -- example the Vortex Sparc II, a very fine piece of equipment for its build value, and works great on my MechTech.
However, when I mount it on my S2k, I have quite a bit of viewing obstruction with the stock sights on the Gen2 unit, and I have full co-witness of the optic.
I'm not keen on the 45* offset, even if the weapon folds and locks, the protrusion for many tubes still makes it a bit clunky for easy and slim storage.
For me, I will stick with the irons, and leave my RDS for the MechTech and other equipment better suited for them.